Blar i NTNU Open på forfatter "Parmar, Naveen"

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    • BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia 

      Lindholm, Håvard Takle; Parmar, Naveen; Drurey, Claire; Poveda, Marta Campillo; Vornewald, Pia; Ostrop, Jenny; Sanchez, Alberto Diez; Maizels M, Rick; Oudhoff, Menno (Peer reviewed; Journal article, 2022)
      Intestinal parasite infections or allergic reactions promote IL-13–induced differentiation of tuft cells as one manifestation of type 2 immunity in the gut. Using organoid cultures of intestinal epithelial cells, Lindholm ...

    • Intestinal-epithelial LSD1 controls goblet cell maturation and effector responses required for gut immunity to bacterial and helminth infection 

      Parmar, Naveen; Burrows, Kyle; Vornewald, Pia M.; Lindholm, Håvard T.; Zwiggelaar, Rosalie T.; Díez-Sánchez, Alberto; Martín-Alonso, Mara; Fosslie, Madeleine; Vallance, Bruce A.; Dahl, John Arne; Zaph, Colby; Oudhoff, Menno J. (Peer reviewed; Journal article, 2021)
      Infectious and inflammatory diseases in the intestine remain a serious threat for patients world-wide. Reprogramming of the intestinal epithelium towards a protective effector state is important to manage inflammation and ...

    • LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium 

      Zwiggelaar, Rosalie; Lindholm, Håvard Takle; Fosslie, Madeleine Lystad; Pedersen, Marianne Terndrup; Ohta, Yuki; Díez-Sánchez, Alberto; Martín-Alonso, Mara; Ostrop, Jenny; Matono, Mami; Parmar, Naveen; Kvaløy, Emilie; Spanjers, Roos; Nazmi, Kamran; Rye, Morten Beck; Drabløs, Finn; Arrowsmith, Cheryl H; Dahl, John Arne; Jensen, Kim B.; Sato, Toshiro; Oudhoff, Menno (Journal article; Peer reviewed, 2020)
      Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify regulators of neonatal intestinal epithelial ...

    • Mmp17- deficient mice exhibit heightened goblet cell effector expression in the colon and increased resistance to chronic Trichuris muris infection 

      Vornewald, Pia Magdalena; Forman, Ruth; Yao, Rouan; Parmar, Naveen; Lindholm, Håvard Takle; Lee, Lilith Sian Kaspersen; Martin Alonso, Mara; Else, Kathryn J.; Oudhoff, Menno Johannes (Peer reviewed; Journal article, 2023)
      Intestinal epithelial homeostasis is maintained by intrinsic and extrinsic signals. The extrinsic signals include those provided by mesenchymal cell populations that surround intestinal crypts and is further facilitated ...